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目的:评估强脉冲光联合果酸治疗面部痤疮后红斑及色素沉着的疗效和安全性。方法:2019年1月至2022年12月，广西壮族自治区皮肤病医院皮肤科收集痤疮后红斑及色素沉着患者108例，男30例、女78例，年龄20～44(28.2±5.1)岁；分为强脉冲光组40例、果酸组38例、联合组(强脉冲光联合果酸组)30例。比较3组疗效。用VISIA皮肤分析仪采集患者面部生物学特征数据，比较3组治疗前后的变化。结果:强脉冲光组、果酸组、联合组治疗有效率分别为57.5%(23/40)、50.0%(19/38)、80.0%(24/30)，差异有统计学意义(χ 2＝6.70， P＝0.04)。强脉冲光组与果酸组有效率差异无统计学意(χ 2＝0.44， P＝0.51)，强脉冲光组与联合组、果酸组与联合组有效率差异均有统计学意义(χ 2＝3.93、6.49，均 P<0.05)。3组患者治疗后红斑、斑点、毛孔、紫质VISIA评分值较治疗前下降(均 P<0.05)。各观测值的VISIA评分随着治疗次数的增加呈下降趋势( P<0.01)。治疗期间，未见明显的不良反应。 结论:强脉冲光联合果酸治疗痤疮后红斑及色素沉着能提高疗效，不良反应较少。

Objective:To evaluate the clinical efficacy and safety of intense pulsed light combined with fruit acid in the treatment of erythema and pigmentation after facial acne.Methods:From January 2019 to December 2022, 108 patients were selected from Dermatology Hospital of Guangxi Zhuang Autonomous Region, including 30 males and 78 females, aged 20-44 (28.2±5.1) years. The patients were divided into three groups: intense pulsed light group (40 cases), fruit acid group (38 cases) and intense pulsed light combined with fruit acid group (30 cases). The clinical efficacy of the three groups was compared. The facial biological characteristics data of patients were collected with VISIA skin analyzer and the changes compared before and after treatment in each group.Results:The total effective rates of the intense pulsed light group, the fruit acid group and the combination group were 57.5% (23/40 cases), 50.0% (19/38 cases), and 80.0% (24/30 cases), respectively. Comparison of total effective rates among three groups, there were statistically significant differences (χ 2=6.70, P=0.04). Comparison of effective rates among different groups showed that there was no difference between the intense pulsed light group and the fruit acid group (χ 2=0.44, P=0.51); there were significant difference between the intense pulse light group and the combination group (χ 2=3.93, 6.49; P<0.05), and between the fruit acid group and the combination group (χ 2=6.49, P=0.01). After treatment, the VISIA scores of erythema, spots, pores, and purple in three groups of patients significantly decreased compared to before treatment ( P<0.05). The VISIA scores of each observation value showed a decreasing trend with the increase of treatment frequency ( P<0.01). During the treatment, no obvious adverse reactions were observed. Conclusions:Intense pulsed light combined with fruit acid in the treatment of facial erythema postacnes and postinflammatory hyperpigmentation can improve the efficacy and less adverse reactions.