Abstract： Objective:To explore the application effect of Teach-back health education model in improving discharge readiness, discharge guidance quality and mental toughness of stroke patients..Methods:A total of 96 stroke patients admitted to the Department of Neurology and Surgery, Affiliated Central Hospital of Jiangnan University from August 2021 to July 2022 were selected as the research objects, and they were divided into the control group and the intervention group by random number method. The control group received routine care, while the intervention group received Teach-back health education on the basis of routine care.The data of Readiness for Hospital Discharge Scale (RHDS), Quality of Discharge Teaching Scale (QDTS) and Connor-Davidson resilience scale(CD-RISC) for stroke patients were compared between the two groups.Results:At discharge, RHDS score in the intervention group [(117.03±6.63) points] was higher than that in the control group[ (95.59±13.44) points], and the difference was statistically significant ( P<0.05). The QDTS score in the intervention group [(169.87±8.81) points] was higher than that in the control group [(140.66±20.98) points], and the difference was statistically significant ( P<0.05).The total score of CD-RISC in the intervention group[ (74.26±14.36) points]was higher than that in the control group[ (64.35±12.77)points], and the difference was statistically significant ( P<0.05). Conclusions:Teach-back health education model can significantly improve patients' discharge readiness, discharge guidance quality and mental toughness. This model can achieve better practical results in the discharge readiness of stroke patients, which is helpful to help patients maximize the knowledge related to stroke, enhance their mental toughness and improve the quality of life after stroke.